MUSCLE DISEASE

Head

 

Prof. Dr. med. Stefan Vielhaber

 

The Neuromuscular Center is part of the Department of Neurology at the University of Magdeburg and connected to the German Neuromuscular Disease Association. The aims of our Unit are optimal diagnosis and treatment of patients with neuromuscular diseases, research into skeletal muscle and bioenergitc function of muscle. The Neuomuscular Center offers patients an environment in which all aspects of their illness can be comprehensively examined, and in which optimal treatment can be provided. This requires a complex interaction of several work-groups within the institution, such as highly specialised doctors, social workers, physiotherapists and also co-operation with other departments, such as Neuropathology, Human Genetics, Pediatrics and Biochemistry.

 

Diagnostic tools and research interests

 

In our institution the full spectrum of histological, biochemical and genetical techniques for work-up of muscle specimens from patients with various disorders are available. Furthermore, human studies with modern neuroimaging techniques such as in vivo and in vitro magnetic resonance spectroscopy are performed. Particular emphasis is placed on the role of mitochondrial processes in the major neurodegenerative diseases such as ALS (amyotrophic lateral sclerosis), muscular dystrophies and in known mitochondrial diseases, such as MELAS and CPEO. Furthermore, we offer in patients with chronic muscle pain a diagnostic work up (Fibromyalgia and other syndromes). The differential spectrum includes also autoimmune diseases, especially myasthenic syndromes, polymyositis and neuropathies.

 

DGKN-Jahrestagung 2008

Aktuelles Update zu ALS

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Relevant Publications

 

  • Vielhaber S., Kunz D., Winkler K., Wiedemann F.R., Kirches E., Feistner H., Heinze H.J., Elger C.E., Schubert W., Kunz W.S. (2000) Mitochondrial DNA abnormalities in skeletal muscle of patients with sporadic amyotrophic lateral sclerosis. Brain 123:1339-1348.
  • Vielhaber S., Kaufmann J., Kanowski M., Sailer M., Feistner H., Tempelmann C., Elger C.E., Heinze HJ., Kunz W.S. Effect of creatine supplementation on metabolite levels in ALS motor cortices. (2001) Exp. Neurol. 172:377-382.
  • Vielhaber S., Schrö der R., Winkler K, Weis S., Sailer M., Feistner H., Heinze H.J., Schrö der J.M., Kunz W.S. Defective mitochondrial oxidative phosphorylation in myopathies with tubular aggregates originating from sarcoplasmic reticulum. (2001) J. Neuropath. Exp. Neurol. 60:1032-1040.
  • Vielhaber S., Jakubiczka S., Schrö der J.M., Sailer M., Feistner H., Heinze H.J., Wieacker P., Bettecken Th. Facioscapulohumeral Muscular Dystrophy (FSHD) with EcoRI/BlnI fragment size of more than 32kb. (2002) Muscle and Nerve 25:540-548.
  • Vielhaber S., Varlamov D.A., Kudina T.A., Schrö der R., Kappes-Horn K.; Elger C.E., Seibel M., Seibel P., Kunz, W.S (2002) Expression pattern of mitochondrial respiratory chain enzymes in skeletal muscle of patients harbouring the A3243G point mutation or large scale deletions of mitochondrial DNA. J. Neuropath. Exp. Neurol., 61:885-895.
  • Vielhaber, S., v. Oertzen, J.H., Kudin, A., Schoenfeld, A., Menzel, C., Biersack, H.-J., Kral, T., Elger, C.E., Kunz, W.S. (2003) Correlation of hippocampal glucose oxidation capacity and interictal FDG-PET in temporal lobe epilepsy. Epilepsia 44:193-199.
  • Vielhaber, S., Kudin, A., Winkler, K., Wiedemann, F., Schrö der, R., Feistner, H., Heinze, H.-J., Elger, C.E., Kunz, W.S. (2003) Is there mitochondrial dysfunction in amyotrophic lateral sclerosis skeletal muscle? Ann. Neurol. 53:686-687.
  • Vielhaber, S., Kudin, A.P., Kudina, T.A., Stiller, D., Scheich, H., Schoenfeld, A., Feistner, H., Heinze, H.-J., Elger, C.E. & Kunz, W.S. (2003) Hippocampal N-acetyl aspartate levels do not mirror neuronal cell densities in creatine-supplemented epileptic rats. Eur. J. Neurosci. 18:2292-2300.
  • Kudin, A.P., Bimpong-Buta, N.Y., Vielhaber, S.., Elger, C.E., Kunz & W.S. (2004) Characterization of superoxide producing sites in isolated brain mitochondria. J. Biol. Chem. 279(6):4127-4135.
  • Jakubiczka, S., Vielhaber, S., Kress, W., Kupferling, P., Reuner, U., Kunath, B. & Wieacker, P. (2004) Improvement of the diagnostic procedure in proximal myotonic myopathy/myotonic dystrophy type 2. Neurogenetics 5:55-59.
  • Vielhaber, S., Feistner, H., Weis, J., Kreuder, J., Sailer, M., Schrö der, M. & Kunz W.S. (2004) Two mild clinical courses of primary carnitine deficiency with adult onset lipid storage myopathy. J. Clin. Neurosci. in press.

 

Contact


Prof. Dr. med. Stefan Vielhaber (Facharzt für Neurologie)
Otto-von-Guericke University
University Department of Neurology
And University Department of Stereotactic Neurosurgery
University Medical Center Magdeburg A.ö.R
Leipziger Str. 44
39120 Magdeburg,
Germany


Tel: +49 (0391) 67-13431
Fax: +49 (0391) 67-15233
E-mail:  stefan.vielhaber@med.ovgu.de
URL:     http://neuro2.med.uni-magdeburg.de/~vielhab

 


Histochemical work up in human metabolic myopathy